Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary.

When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- - Acepromazine
  - Alfentanil
  - Alprazolam
  - Amobarbital
  - Anileridine
  - Aripiprazole
  - Asenapine
  - Baclofen
  - Benperidol
  - Benzhydrocodone
  - Bromazepam
  - Buprenorphine
  - Buspirone
  - Butabarbital
  - Butorphanol
  - Calcifediol
  - Calcium Oxybate
  - Cannabidiol
  - Carbinoxamine
  - Carisoprodol
  - Carphenazine
  - Chloral Hydrate
  - Chlordiazepoxide
  - Chlorpromazine
  - Chlorzoxazone
  - Clobazam
  - Clonazepam
  - Clorazepate
  - Clozapine
  - Codeine
  - Cyclobenzaprine
  - Daridorexant
  - Dexmedetomidine
  - Diacetylmorphine
  - Diazepam
  - Dichloralphenazone
  - Difenoxin
  - Dihydrocodeine
  - Diphenhydramine
  - Diphenoxylate
  - Doxylamine
  - Droperidol
  - Enflurane
  - Esketamine
  - Estazolam
  - Eszopiclone
  - Ethchlorvynol
  - Ethopropazine
  - Ethylmorphine
  - Fentanyl
  - Flibanserin
  - Flunitrazepam
  - Fluphenazine
  - Flurazepam
  - Fluspirilene
  - Fospropofol
  - Gabapentin Enacarbil
  - Halazepam
  - Haloperidol
  - Halothane
  - Hexobarbital
  - Hydrocodone
  - Hydromorphone
  - Hydroxyzine
  - Isoflurane
  - Ketamine
  - Ketazolam
  - Ketobemidone
  - Levocetirizine
  - Levorphanol
  - Lorazepam
  - Loxapine
  - Magnesium Oxybate
  - Meclizine
  - Melperone
  - Meperidine
  - Mephobarbital
  - Meprobamate
  - Meptazinol
  - Mesoridazine
  - Metaxalone
  - Methadone
  - Methdilazine
  - Methocarbamol
  - Methohexital
  - Methotrimeprazine
  - Methylene Blue
  - Midazolam
  - Molindone
  - Moricizine
  - Morphine
  - Morphine Sulfate Liposome
  - Nalbuphine
  - Nicomorphine
  - Nitrazepam
  - Nitrous Oxide
  - Olanzapine
  - Opium
  - Opium Alkaloids
  - Orlistat
  - Orphenadrine
  - Oxazepam
  - Oxycodone
  - Oxymorphone
  - Papaveretum
  - Paregoric
  - Pentazocine
  - Pentobarbital
  - Perampanel
  - Perazine
  - Periciazine
  - Perphenazine
  - Phenobarbital
  - Pimozide
  - Piperacetazine
  - Pipotiazine
  - Piritramide
  - Potassium Oxybate
  - Prazepam
  - Pregabalin
  - Primidone
  - Prochlorperazine
  - Promazine
  - Promethazine
  - Propofol
  - Quazepam
  - Quetiapine
  - Ramelteon
  - Remifentanil
  - Remimazolam
  - Remoxipride
  - Ropeginterferon Alfa-2b-njft
  - Secobarbital
  - Sertindole
  - Sodium Oxybate
  - Sufentanil
  - Sulpiride
  - Suvorexant
  - Tapentadol
  - Temazepam
  - Thiethylperazine
  - Thiopental
  - Thiopropazate
  - Thioridazine
  - Tilidine
  - Tizanidine
  - Tolonium Chloride
  - Topiramate
  - Tramadol
  - Triazolam
  - Trifluoperazine
  - Trifluperidol
  - Triflupromazine
  - Trimeprazine
  - Zaleplon
  - Zolpidem
  - Zopiclone
  - Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aluminum Carbonate, Basic
Aluminum Hydroxide
Aluminum Phosphate
Dihydroxyaluminum Aminoacetate
Dihydroxyaluminum Sodium Carbonate
Ginkgo
Magaldrate
Magnesium Carbonate
Magnesium Hydroxide
Magnesium Oxide
Magnesium Trisilicate

Gabapentin and Alcohol/Food Interactions

Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Do not use more than the recommended dose of gabapentin, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Gabapentin Disease Interactions

Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use of excessive dosages, and abrupt cessation and/or a reduction in dosage may precipitate withdrawal symptoms. In patients who have developed tolerance, overdosage can still produce respiratory depression and death.

Therapy with anxiolytic, sedative, and hypnotic agents should be administered cautiously and for as brief a period as possible. Addiction-prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance or medical supervision when treated with these agents.

In addition, it may be prudent to refrain from dispensing large quantities of medication to such patients. After prolonged use or if dependency is suspected, withdrawal of medication should be undertaken gradually using a dosage-tapering schedule.