What is fioricet ?

Fioricet contains a combination of acetaminophen, butalbital, and caffeine. Acetaminophen is a pain reliever and fever reducer. Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Fioricet Chemical Structure
Fioricet Chemical Structure

Fioricet is used to treat tension headaches that are caused by muscle contractions.

Fioricet® (Butalbital, Acetaminophen, and Caffeine Tablets USP) is supplied in tablet form for oral administration.

Each tablet contains the following active ingredients:
butalbital USP . . . . . . . . . . . .50 mg
acetaminophen USP . . . . . . 325 mg
caffeine USP . . . . . . . . . . . . .40 mg

Butalbital has generalized depressant effect on central nervous system and, in very high doses, has peripheral effects. Acetaminophen has analgesic and antipyretic effects mediated by a metabolite which acts at cannabinoid receptors, contrary to popular belief it is not an antiinflammatory at safe levels (it becomes toxic at doses above 1,000mg per dose and/or 3,000mg per day). Caffeine is thought to produce constriction of cerebral blood vessels and serves to counteract the sedative effect of butalbital.

Butalbital has a half-life of about 35 hours. Acetaminophen has a half-life of about 1.25 to 3 hours, but may be increased by liver damage and after an overdose. Caffeine has a half-life of about 5 to 7 hours.

Fioricet (butalbital/acetaminophen/caffeine) has been around forever and is used by many for the treatment of chronic migraine or tension headaches. It is a mixture of a barbiturate, Tylenol (acetaminophen) and caffeine.

Now, many formularies are no longer covering Fioricet capsules. For those of you who have relied on it for years, this (understandably) may make you nervous.

Well, it turns out it doesn’t really work that well—and there are much better options out there.

  • Fioricet and Fioricet with Codeine are not as effective for acute migraine as newer medications. There isn’t any evidence that shows that barbiturate-containing meds (the butalbital in Fioricet) help for migraine treatment. In fact, the use of Fioricet with Codeine often results in chronic migraine and a “medication overuse headache.”
  • NSAIDS. Start with these instead. There is good evidence that nonsteroidal anti-inflammatory drugs—ibuprofen, naproxen, and others—work well for the treatment of acute migraine.
  • Triptans. Imitrex (sumatriptan), Maxalt (rizatriptan), Relpax (eletriptan), and Frova (frovatriptan) are examples. Used alone or in combination with an NSAID, triptans work well for moderate to severe headaches that aren’t relieved by NSAIDs alone. Wondering which to choose? They generally work the same but you may notice fewer side effects with one over the other. Cost can also be an issue so you’ll want to pick a triptan that is covered by your insurance plan. It’s also a good idea to check GoodRx to see if the cash or discount price beats your co-pay.
  • Adding a nausea medication. For folks with moderate to severe migraine accompanied by nausea or vomiting, adding Reglan (metoclopramide) , Zofran (ondansetron) or Compazine (prochlorperazine) also helps.

Bottom line is . . . while your Fioricet capsules may no longer be covered, better options exist.

What is side effects of Generic Fioricet ?

Nausea, vomiting, abdominal pain, shaking (tremor), shortness of breath, increased urination, lightheadedness, dizziness, drowsiness, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To reduce your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Stop using Fioricet and call your doctor at once if you have:

  • confusion, seizure (convulsions);
  • shortness of breath;
  • a light-headed feeling, like you might pass out; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

What Are the Possible Side-Effects of Fioricet?

Like any medication, Fioricet can cause side-effects. People who misuse Fioricet or use it compulsively are at greater risk for experiencing the worst side-effects of the medication.

The possible side-effects of Fioricet are:

      • Anxiety
      • Dizziness
      • Drowsiness
      • Feelings of being intoxicated
      • Lightheadedness
      • Nausea and vomiting
      • Shaking and tremors
      • Shortness of breath
      • Stomach pain
      • Trouble sleeping

In some cases, a person who takes Fioricet may develop an allergic reaction to the drug. The symptoms of an allergic reaction are trouble breathing, itching, rashes, intense dizziness, and swelling in the face, throat, and tongue.

What are the Symptoms of a Fioricet Overdose?

While butalbital is the addictive ingredient in Fioricet, acetaminophen is the ingredient which is liable to cause an overdose. Unfortunately, people who misuse Fioricet as a recreational drug or as a way to suppress withdrawal are most likely to suffer an overdose.

When a person overdoses on Fioricet, the acetaminophen will damage their liver. In severe cases, an overdose can even provoke fatal liver failure. For this reason, it is dangerous to take Fioricet together with another medication which contains acetaminophen because it increases the risk of overdose and death. Furthermore, drinking alcohol while taking Fioricet may also inflict liver damage.

A Fioricet overdose is a medical emergency, so it’s important to know the symptoms. An overdose on Fioricet and all other forms of liver failure cause jaundice, the yellowing of the skin and eyes. Other symptoms of an overdose include:

    • Confusion
    • Convulsions and seizures
    • Fainting
    • Irregular heartbeat
    • Lack of appetite
    • Nausea and vomiting
    • Restlessness
    • Stomach pain
    • Sweating
    • Tremors

What should I avoid while I am taking Fioricet?

Fioricet can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Mikart Fioricet
Mikart Fioricet

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

While you are taking Fioricet, avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice.

Medicines that interact with Fioricet may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Fioricet. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with Fioricet include:

  • antidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), or SSRIs (eg, fluoxetine, sertraline)
  • anticonvulsants, such as carbamazepine, divalproex, lamotrigine, phenytoin, phenobarbital, or primidone
  • antipsychotics (such as butyrophenones, phenothiazines, or thioxanthenes) and atypical antipsychotics (eg, olanzapine, quetiapine, ziprasidone)
  • any medication that may cause drowsiness, such as amphetamines, benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as codeine, fentanyl or morphine)
  • buprenorphine
  • cannabis
  • cyclosporine
  • dextromethorphan
  • duloxetine
  • heart medications such as diltiazem or verapamil
  • HIV medications such as ritonavir
  • migraine medications, such as ergotamine or dihydroergotamine
  • muscle relaxants, such as cyclobenzaprine
  • naltrexone
  • other medications that contain acetaminophen or an opioid either in combination or as the sole ingredient
  • pentazocine
  • prilocaine
  • rifampin
  • sodium oxybate
  • tamsulosin
  • tramadol
  • warfarin.

Gabapentin Manufactures

Gabapentin Manufactures

    • Actavis elizabeth llc
    • Amneal pharmaceuticals ny llc
    • Apotex inc etobicoke site
    • Aurobindo pharma usa inc
    • Hikma pharmaceuticals
    • Invagen pharmaceuticals inc
    • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
    • Mutual pharmaceutical co inc
    • Ranbaxy laboratories ltd
    • Sandoz inc
    • Sun pharmaceutical industries ltd
    • Teva pharmaceuticals usa
    • Watson laboratories inc
    • Pfizer pharmaceuticals ltd
    • Parke davis div warner lambert co
    • Glenmark generics ltd
    • Matrix laboratories ltd
    • Teva pharmaceuticals usa inc

Gabapentin Packagers

 

    • 4uOrtho LLC
    • Actavis Group
    • Aidarex Pharmacuticals LLC
    • Amerisource Health Services Corp.
    • Amneal Pharmaceuticals
    • Apotex Inc.
    • Apotheca Inc.
    • A-S Medication Solutions LLC
    • Aurobindo Pharma Ltd.
    • Blenheim Pharmacal
    • Blu Pharmaceuticals LLC
    • Bryant Ranch Prepack
    • Camber Pharmaceuticals Inc.
    • Cardinal Health
    • Comprehensive Consultant Services Inc.
    • Corepharma LLC
    • Coupler Enterprises Inc.
    • Dispensing Solutions
    • Diversified Healthcare Services Inc.
    • Eon Labs
    • Fusion Pharmaceuticals LLC
    • Glenmark Generics Ltd.
    • Golden State Medical Supply Inc.
    • Greenstone LLC
    • H.J. Harkins Co. Inc.
    • Heartland Repack Services LLC
    • Hikma Pharmaceuticals
    • Innoviant Pharmacy Inc.
    • Ivax Pharmaceuticals
    • Kaiser Foundation Hospital
    • Keltman Pharmaceuticals Inc.
    • Lake Erie Medical and Surgical Supply
    • Living Well Pharmacy Inc.
    • Major Pharmaceuticals
    • Mckesson Corp.
    • Medvantx Inc.
    • Murfreesboro Pharmaceutical Nursing Supply
    • Mylan
    • Neuman Distributors Inc.
    • Northstar Rx LLC
    • Nucare Pharmaceuticals Inc.
    • Palmetto Pharmaceuticals Inc.
    • PCA LLC
    • PD-Rx Pharmaceuticals Inc.
    • Pfizer Inc.
    • Pharmaceutical Packaging Center
    • Pharmacy Service Center
    • Physicians Total Care Inc.
    • Preferred Pharmaceuticals Inc.
    • Prepak Systems Inc.
    • Professional Co.
    • Ranbaxy Laboratories
    • Rebel Distributors Corp.
    • Remedy Repack
    • Resource Optimization and Innovation LLC
    • Sandhills Packaging Inc.
    • Southwood Pharmaceuticals
    • St Mary’s Medical Park Pharmacy
    • Stat Rx Usa
    • Sun Pharmaceutical Industries Ltd.
    • Teva Pharmaceutical Industries Ltd.
    • UDL Laboratories
    • United Research Laboratories Inc.
    • Vangard Labs Inc.
    • Warner Lambert Company LLC
    • West-Ward Pharmaceuticals